Monoclonal Antibodies as Therapeutic Agents

Monoclonal Antibodies as Therapeutic Agents What are antibodies? Antibodies are paragon for the consumption in drug therapies because they are very special in the functions that they carry out in biological sy foots. They bear be described as Y-shaped proteins that consist of four polypeptide irons. Residing in the accouterments of the Y are two identical light polypeptide bonds and the antecedent of the Y consists of two heavy polypeptide chains. The light polypeptide chains that chance on up the arms are referred to as a mythic (Fragment for Antigen Binding) and function by recognising the antibodys target or antigen (antibody generating molecule). The stem of the Y is known as the Fc fortune of the antibody. The stems main graphic type is to communicate with the world immune strategy so that it initiates a series of immunilogical responses. These initiated immunilogical responses include ADCC (Antibody Dependent Cellular Cytotoxicity) in which authoritative huma n immune system cells bind to the Fc via specific antibody proceed song receptors. These immune cells are then signalled to destroy the encroaching(a) entity, a molecule or a whole cell, to which the antibody is bound. The complement system is another immune response that can be initiated, where a series of blood proteins bind to the Fc and subsequently promote remnant of the invading target.

An important factor in the aptitude of antibody therapeutics is that the Fc portion also provides for the long half-life of the antibody within the blood. The register of antibody research. In the youthful 1800s scien tists discovered that blood serum which was ! interpreted from mice that were immunised (exposed to) with human proteins contained a mixture of mouse antibodies that could be used to combat certain diseases. This, however, was problematic in that there was no technology available at the time to larn sufficient quantities of... If you loss to get a full essay, secernate it on our website: OrderCustomPaper.com

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